Welcome to the OPTIMAS website

Review paper: This in-depth review paper by David Seiffge and collaborators highlights OPTIMAS as one of the important trials assessing the optimal timing of DOAC in stroke patients with AF!

Trial update: The OPTIMAS trial concluded its recruitment phase on 31st January 2024. Our 100 sites collectively recruited 3648 participants, far exceeding our original recruitment target! The trial is now in follow-up.

OPTIMAS scientific update: five key messages following the publication of the ELAN clinical trial (19-Jul-2023)

OPTIMAS protocol paper: Please have a look to learn all about the work we've been doing these past 4 years (June 2022)

OPTIMAS scientific update: Unsure on equipoise and identifying suitable potential participants? Please see our equipoise document for guidance (11-Jan-2022)

UK government report on the future of UK clinical research delivery: the OPTIMAS trial was mentioned! (23-Mar-2021)

This trial, funded by the British Heart Foundation, aims to answer one of the key clinical challenges in stroke medicine: what is the optimal timing of anticoagulation in acute ischaemic stroke associated with atrial fibrillation? We are looking forward to working with research teams around the UK to complete the trial and improve the care of patients with stroke.

David Werring - Chief Investigator

Access Sealed Envelope here

Access MACRO here

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